Evaluation of 124I-JS001 for hPD1 immuno-PET imaging using sarcoma cell homografts in humanized mice

Evaluation of 124I-JS001 for hPD1 immuno-PET imaging using sarcoma cell homografts in humanized mice

JS001 (toripalimab) is a humanized IgG monoclonal antibody which strongly inhibits programmed cell death protein 1 (PD1). In this study, we used a different iodine isotype (nat/124/125I) to label JS001 probes to target the human PD1 (hPD1) antigen. In vitro, the half maximal effective concentration...

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Bibliographic Details
Main Authors: Haifeng Huang, Hua Zhu, Quan Xie, Xiaobin Tian, Xianteng Yang, Fan Feng, Qiyu Jiang, Xinan Sheng, Zhi Yang
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Immunotherapy
JS001
Toripalimab
Programmed cell death protein 1
Immuno-PET imaging
Iodine isotopes
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383519310214

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http://www.sciencedirect.com/science/article/pii/S2211383519310214

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