Evidence for a protective effect of the loss of α4-containing nicotinic acetylcholine receptors on Aβ-related neuropathology in Tg2576 mice

Evidence for a protective effect of the loss of α4-containing nicotinic acetylcholine receptors on Aβ-related neuropathology in Tg2576 mice

IntroductionLoss of cholinergic neurons as well as α4β2* (* = containing) nicotinic acetylcholine receptors (nAChRs) is a prominent feature of Alzheimer’s disease (AD). Specifically, amyloid β (Aβ), the principal pathogenic factor of AD, is a high affinity ligand for nAChRs. Yet, the pathophysiologi...

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Bibliographic Details
Main Authors: Antonietta Vilella, Benedetto Romoli, Martina Bodria, Stéphanie Pons, Uwe Maskos, Michele Zoli
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Neuroscience
Subjects:
α4-containing nicotinic acetylcholine receptors
microglia
Alzheimer’s disease
Tg2576
APPswe
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1097857/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2023.1097857/full

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