Characterization of a novel non-steroidal glucocorticoid receptor agonist optimized for topical treatment

Characterization of a novel non-steroidal glucocorticoid receptor agonist optimized for topical treatment

Abstract Glucocorticoids (GCs) are commonly used topical treatments for skin diseases but are associated with both local and systemic side effects. In this study, we describe a selective non-steroidal glucocorticoid receptor (GR) agonist for topical use, LEO 134310, which is rapidly deactivated in t...

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Bibliographic Details
Main Authors: Stefan Eirefelt, Martin Stahlhut, Naila Svitacheva, Martin A. Carnerup, Joel Mauricio Correa Da Rosa, David Adrian Ewald, Troels T. Marstrand, Mikkel Krogh-Madsen, Georg Dünstl, Kevin Neil Dack, Anna Ollerstam, Hanne Norsgaard
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-05471-w

Internet

https://doi.org/10.1038/s41598-022-05471-w

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