p90RSK2, a new MLCK mediates contractility in myosin light chain kinase null smooth muscle

p90RSK2, a new MLCK mediates contractility in myosin light chain kinase null smooth muscle

Introduction: Phosphorylation of smooth muscle (SM) myosin regulatory light chain (RLC20) is a critical switch leading to SM contraction. The canonical view held that only the short isoform of myosin light chain kinase (MLCK1) catalyzed this reaction. It is now accepted that auxiliary kinases may co...

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Bibliographic Details
Main Authors: Jaspreet Kalra, Mykhaylo Artamonov, Hua Wang, Aaron Franke, Zaneta Markowska, Li Jin, Zygmunt S. Derewenda, Ramon J. Ayon, Avril Somlyo
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Physiology
Subjects:
smooth muscle
MLCK
mylk1
p90 ribosomal S6 kinase
RSK2
PDK1
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1228488/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1228488/full

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