Hydrogen sulfide donor AP123 restores endothelial nitric oxide-dependent vascular function in hyperglycemia via a CREB-dependent pathway

Hydrogen sulfide donor AP123 restores endothelial nitric oxide-dependent vascular function in hyperglycemia via a CREB-dependent pathway

Diabetes is associated with severe vascular complications involving the impairment of endothelial nitric oxide synthase (eNOS) as well as cystathionine γ-lyase (CSE) activity. eNOS function is suppressed in hyperglycaemic conditions, resulting in reduced NO bioavailability, which is paralleled by re...

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Bibliographic Details
Main Authors: Rosangela Montanaro, Valentina Vellecco, Roberta Torregrossa, Gian Marco Casillo, Onorina Laura Manzo, Emma Mitidieri, Mariarosaria Bucci, Sigismondo Castaldo, Raffaella Sorrentino, Matthew Whiteman, Martina Smimmo, Flavia Carriero, Giuseppe Terrazzano, Giuseppe Cirino, Roberta d’Emmanuele di Villa Bianca, Vincenzo Brancaleone
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Redox Biology
Subjects:
Endothelium
Hyperglycemia
Gasotransmitters
H2S donors
Vascular function
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000587

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http://www.sciencedirect.com/science/article/pii/S2213231723000587

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