Alzheimer's disease genetic risk variants beyond APOE ε4 predict mortality

Alzheimer's disease genetic risk variants beyond APOE ε4 predict mortality

Abstract Introduction We hypothesized that, like apolipoprotein E (APOE), other late‐onset Alzheimer's disease (LOAD) genetic susceptibility loci predict mortality. Methods We used a weighted genetic risk score (GRS) from 21 non‐APOE LOAD risk variants to predict survival in the Adult Changes i...

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Bibliographic Details
Main Authors: Jesse Mez, Jessica R. Marden, Shubhabrata Mukherjee, Stefan Walter, Laura E. Gibbons, Alden L. Gross, Laura B. Zahodne, Paola Gilsanz, Paul Brewster, Kwangsik Nho, Paul K. Crane, Eric B. Larson, M. Maria Glymour
Format: Article
Language:English
Published: Wiley 2017-01-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
Alzheimer's disease
Longevity
Mortality
Survival analysis
Genetic risk score
Selection bias
Online Access:https://doi.org/10.1016/j.dadm.2017.07.002

Internet

https://doi.org/10.1016/j.dadm.2017.07.002

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