Loss of PHF8 induces a viral mimicry response by activating endogenous retrotransposons

Loss of PHF8 induces a viral mimicry response by activating endogenous retrotransposons

Abstract Immunotherapy has become established as major treatment modality for multiple types of solid tumors, including colorectal cancer. Identifying novel immunotherapeutic targets to enhance anti-tumor immunity and sensitize current immune checkpoint blockade (ICB) in colorectal cancer is needed....

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Bibliographic Details
Main Authors: Yanan Liu, Longmiao Hu, Zhengzhen Wu, Kun Yuan, Guangliang Hong, Zhengke Lian, Juanjuan Feng, Na Li, Dali Li, Jiemin Wong, Jiekai Chen, Mingyao Liu, Jiangping He, Xiufeng Pang
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39943-y

Internet

https://doi.org/10.1038/s41467-023-39943-y

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