Inhibition of Rac1-dependent forgetting alleviates memory deficits in animal models of Alzheimer’s disease

Inhibition of Rac1-dependent forgetting alleviates memory deficits in animal models of Alzheimer’s disease

Abstract Accelerated forgetting has been identified as a feature of Alzheimer’s disease (AD), but the therapeutic efficacy of the manipulation of biological mechanisms of forgetting has not been assessed in AD animal models. Ras-related C3 botulinum toxin substrate 1 (Rac1), a small GTPase, has been...

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Bibliographic Details
Main Authors: Wenjuan Wu, Shuwen Du, Wei Shi, Yunlong Liu, Ying Hu, Zuolei Xie, Xinsheng Yao, Zhenyu Liu, Weiwei Ma, Lin Xu, Chao Ma, Yi Zhong
Format: Article
Language:English
Published: Oxford University Press 2019-07-01
Series:Protein & Cell
Subjects:
Alzheimer’s disease
Rac1
forgetting
memory loss
hippocampus
Online Access:http://link.springer.com/article/10.1007/s13238-019-0641-0

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http://link.springer.com/article/10.1007/s13238-019-0641-0

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