METTL1 promotes hepatocarcinogenesis via m7G tRNA modification‐dependent translation control

METTL1 promotes hepatocarcinogenesis via m7G tRNA modification‐dependent translation control

Abstract Background N7‐methylguanosine (m7G) modification is one of the most common transfer RNA (tRNA) modifications in humans. The precise function and molecular mechanism of m7G tRNA modification in hepatocellular carcinoma (HCC) remain poorly understood. Methods The prognostic value and expressi...

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Bibliografiska uppgifter
Huvudupphovsmän: Zhihang Chen, Wanjie Zhu, Shenghua Zhu, Kaiyu Sun, Junbin Liao, Haining Liu, Zihao Dai, Hui Han, Xuxin Ren, Qingxia Yang, Siyi Zheng, Baogang Peng, Sui Peng, Ming Kuang, Shuibin Lin
Materialtyp: Artikel
Språk:English
Publicerad: Wiley 2021-12-01
Serie:Clinical and Translational Medicine
Ämnen:
hepatocellular carcinoma
N7‐methylguanosine
translation control
tRNA modifications
tumour progression
Länkar:https://doi.org/10.1002/ctm2.661

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