METTL1 promotes hepatocarcinogenesis via m7G tRNA modification‐dependent translation control

METTL1 promotes hepatocarcinogenesis via m7G tRNA modification‐dependent translation control

Abstract Background N7‐methylguanosine (m7G) modification is one of the most common transfer RNA (tRNA) modifications in humans. The precise function and molecular mechanism of m7G tRNA modification in hepatocellular carcinoma (HCC) remain poorly understood. Methods The prognostic value and expressi...

書誌詳細
主要な著者:	Zhihang Chen, Wanjie Zhu, Shenghua Zhu, Kaiyu Sun, Junbin Liao, Haining Liu, Zihao Dai, Hui Han, Xuxin Ren, Qingxia Yang, Siyi Zheng, Baogang Peng, Sui Peng, Ming Kuang, Shuibin Lin
フォーマット:	論文
言語:	English
出版事項:	Wiley 2021-12-01
シリーズ:	Clinical and Translational Medicine
主題:	hepatocellular carcinoma N7‐methylguanosine translation control tRNA modifications tumour progression
オンライン･アクセス:	https://doi.org/10.1002/ctm2.661

類似資料

METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
著者:: Raquel García-Vílchez, 等
出版事項: (2023-07-01)

METTL1 promotes neuroblastoma development through m7G tRNA modification and selective oncogenic gene translation
著者:: Ying Huang, 等
出版事項: (2022-09-01)

Novel roles of METTL1/WDR4 in tumor via m7G methylation
著者:: Wenli Cheng, 等
出版事項: (2022-09-01)

tRNA Modifications: Impact on Structure and Thermal Adaptation
著者:: Christian Lorenz, 等
出版事項: (2017-04-01)

Rosmarinic Acid Alleviates Radiation-Induced Pulmonary Fibrosis by Downregulating the tRNA N7-Methylguanosine Modification-Regulated Fibroblast-to-Myofibroblast Transition Through the Exosome Pathway
著者:: Zhang T, 等
出版事項: (2024-08-01)

tRNA Biology in Trypanosomes
著者:: Shikha Shikha, 等
出版事項: (2019-05-01)

Nuclear and mitochondrial tRNA-lookalikes in the human genome
著者:: Aristeidis G Telonis, 等
出版事項: (2014-10-01)

Aminoacyl‐tRNA synthetases in medicine and disease
著者:: Peng Yao, 等
出版事項: (2013-02-01)

METTL1‐m7G‐EGFR/EFEMP1 axis promotes the bladder cancer development
著者:: Xiaoling Ying, 等
出版事項: (2021-12-01)

Multiple Layers of Stress-Induced Regulation in tRNA Biology
著者:: Hsiao-Yun Huang, 等
出版事項: (2016-03-01)

Disrupted tRNA Genes and tRNA Fragments: A Perspective on tRNA Gene Evolution
著者:: Akio Kanai
出版事項: (2015-01-01)

Emerging roles of tRNA-derived fragments in cancer
著者:: Min Fu, 等
出版事項: (2023-02-01)

Genome recoding by tRNA modifications
著者:: Francesca Tuorto, 等
出版事項: (2016-01-01)

Stress Response in Entamoeba histolytica Is Associated with Robust Processing of tRNA to tRNA Halves
著者:: Manu Sharma, 等
出版事項: (2023-04-01)

Role of tRNA-derived small RNAs(tsRNAs) in the diagnosis and treatment of malignant tumours
著者:: Mingwen Mao, 等
出版事項: (2023-07-01)

METTL1-mediated m7G methylation maintains pluripotency in human stem cells and limits mesoderm differentiation and vascular development
著者:: Yujie Deng, 等
出版事項: (2020-07-01)

On distinguishing between canonical tRNA genes and tRNA gene fragments in prokaryotes
著者:: Peter T.S. van der Gulik, 等
出版事項: (2023-12-01)

Aminoacyl-tRNA synthetases of the multi-tRNA synthetase complex and their role in tumorigenesis
著者:: Krishnendu Khan, 等
出版事項: (2022-05-01)

Peptidyl tRNA Hydrolase Is Required for Robust Prolyl-tRNA Turnover in Mycobacterium tuberculosis
著者:: Francesca G. Tomasi, 等
出版事項: (2023-02-01)

tRNA Metabolism and Lung Cancer: Beyond Translation
著者:: Meng Bian, 等
出版事項: (2021-09-01)

On the Track of the Missing tRNA Genes: A Source of Non-Canonical Functions?
著者:: Ricardo Ehrlich, 等
出版事項: (2021-03-01)

The role of tRNA identity elements in aminoacyl-tRNA editing
著者:: Edwin Cruz, 等
出版事項: (2024-07-01)

Mechanisms of tRNA-derived fragments and tRNA halves in cancer treatment resistance
著者:: Yue Zhang, 等
出版事項: (2020-10-01)

tRNA gene content, structure, and organization in the flowering plant lineage
著者:: Kim Carlo Monloy, 等
出版事項: (2024-12-01)

Mettl1-mediated internal m7G methylation of Sptbn2 mRNA elicits neurogenesis and anti-alzheimer’s disease
著者:: Qingfeng Li, 等
出版事項: (2023-10-01)

Editorial: tRNA and protein synthesis in microorganisms
著者:: Matthieu G. Gagnon, 等
出版事項: (2024-10-01)

Aminoacyl-tRNA Synthesis in Methanogenic Archaea
著者:: Dragana Korenčić, 等
出版事項: (2002-01-01)

Novel Perspectives on Chloroplast tRNA Genomic and Structural Variations Imply the Evolution of Papilionoideae (Fabaceae)
著者:: Shiyun Han, 等
出版事項: (2024-08-01)

The Aminoacyl-tRNA Synthetase and tRNA Expression Levels Are Deregulated in Cancer and Correlate Independently with Patient Survival
著者:: Anmolpreet Kaur Sangha, 等
出版事項: (2022-07-01)

Trypanosoma brucei multi-aminoacyl-tRNA synthetase complex formation limits promiscuous tRNA proofreading
著者:: Rylan R. Watkins, 等
出版事項: (2024-07-01)

Toward an Understanding of Extracellular tRNA Biology
著者:: Adrian Gabriel Torres, 等
出版事項: (2021-04-01)

METTL1 mediated tRNA m7G modification promotes leukaemogenesis of AML via tRNA regulated translational control
著者:: Pan Zhao, 等
出版事項: (2024-01-01)

tRNA modifications: greasing the wheels of translation and beyond
著者:: Minjie Zhang, 等
出版事項: (2025-12-01)

Mutational analysis of mitochondrial tRNA genes in patients with lung cancer
著者:: He ZF, 等
出版事項: (2016-12-01)

Origin of Type II tRNA Variable Loops, Aminoacyl-tRNA Synthetase Allostery from Distal Determinants, and Diversification of Life
著者:: Lei Lei, 等
出版事項: (2024-08-01)

The host tRNA epitranscriptome: A new player in RNA virus infections
著者:: Marc Talló-Parra, 等
出版事項: (2022-12-01)

Theoretical study of fMet-tRNA and fAla-tRNA structures by using quantum calculation
著者:: M. Noei, 等
出版事項: (2016-11-01)

A robust method for measuring aminoacylation through tRNA-Seq
著者:: Kristian Davidsen, 等
出版事項: (2024-07-01)

The Typical tRNA Co-Expresses Multiple 5′ tRNA Halves Whose Sequences and Abundances Depend on Isodecoder and Isoacceptor and Change with Tissue Type, Cell Type, and Disease
著者:: Robert Brian Akins, 等
出版事項: (2023-11-01)

Variation of tRNA modifications with and without intron dependency
著者:: Sachiko Hayashi
出版事項: (2024-09-01)