Adapting SHIVs In Vivo Selects for Envelope-Mediated Interferon-α Resistance.

Lentiviruses are able to establish persistent infection in their respective hosts despite a potent type-I interferon (IFN-I) response following transmission. A number of IFN-I-induced host factors that are able to inhibit lentiviral replication in vitro have been identified, and these studies sugges...

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Bibliographic Details
Main Authors: David F Boyd, Amit Sharma, Daryl Humes, Cecilia Cheng-Mayer, Julie Overbaugh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4939950?pdf=render