Identification of Histone Lysine Acetoacetylation as a Dynamic Post‐Translational Modification Regulated by HBO1

Identification of Histone Lysine Acetoacetylation as a Dynamic Post‐Translational Modification Regulated by HBO1

Abstract Ketone bodies have long been known as a group of lipid‐derived alternative energy sources during glucose shortages. Nevertheless, the molecular mechanisms underlying their non‐metabolic functions remain largely elusive. This study identified acetoacetate as the precursor for lysine acetoace...

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Bibliographic Details
Main Authors: Yan Gao, Xinlei Sheng, Doudou Tan, SunJoo Kim, Soyoung Choi, Sanjita Paudel, Taeho Lee, Cong Yan, Minjia Tan, Kyu Min Kim, Sam Seok Cho, Sung Hwan Ki, He Huang, Yingming Zhao, Sangkyu Lee
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Advanced Science
Subjects:
acetoacetate
acetoacetylation
epigenetics
HBO1
histone marks
novel histone modification
Online Access:https://doi.org/10.1002/advs.202300032

Internet

https://doi.org/10.1002/advs.202300032

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