Functional Characterization of Novel <i>MC4R</i> Variants Identified in Two Unrelated Patients with Morbid Obesity in Qatar

Functional Characterization of Novel <i>MC4R</i> Variants Identified in Two Unrelated Patients with Morbid Obesity in Qatar

The leptin–melanocortin pathway is pivotal in appetite and energy homeostasis. Pathogenic variants in genes involved in this pathway lead to severe early-onset monogenic obesity (MO). The <i>MC4R</i> gene plays a central role in leptin–melanocortin signaling, and heterozygous variants in...

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Bibliographic Details
Main Authors: Idris Mohammed, Senthil Selvaraj, Wesam S. Ahmed, Tara Al-Barazenji, Ayat S Hammad, Hajar Dauleh, Luis R. Saraiva, Mashael Al-Shafai, Khalid Hussain
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
<i>MC4R</i>
monogenic obesity
severe obesity
childhood obesity
Qatar
Online Access:https://www.mdpi.com/1422-0067/24/22/16361

Internet

https://www.mdpi.com/1422-0067/24/22/16361

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