The Histone H3 K4me3, K27me3, and K27ac Genome-Wide Distributions Are Differently Influenced by Sex in Brain Cortexes and Gastrocnemius of the Alzheimer’s Disease PSAPP Mouse Model

The Histone H3 K4me3, K27me3, and K27ac Genome-Wide Distributions Are Differently Influenced by Sex in Brain Cortexes and Gastrocnemius of the Alzheimer’s Disease PSAPP Mouse Model

Background: Women represent the majority of Alzheimer’s disease patients and show typical symptoms. Genetic, hormonal, and behavioral mechanisms have been proposed to explain sex differences in dementia prevalence. However, whether sex differences exist in the epigenetic landscape of neuronal tissue...

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Bibliographic Details
Main Authors: Francesca Casciaro, Giuseppe Persico, Martina Rusin, Stefano Amatori, Claire Montgomery, Jennifer R. Rutkowsky, Jon J. Ramsey, Gino Cortopassi, Mirco Fanelli, Marco Giorgio
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Epigenomes
Subjects:
Alzheimer’s disease
sex differences
PSAPP mice
histone marks
Online Access:https://www.mdpi.com/2075-4655/5/4/26

Internet

https://www.mdpi.com/2075-4655/5/4/26

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