A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation

A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation

Polycystin-1 (PC-1, PKD1), a receptor-like protein expressed by the Pkd1 gene, is present in a wide variety of cell types, but its cellular location, signaling mechanisms, and physiological functions are poorly understood. Here, by studying tamoxifen-inducible, endothelial cell (EC)-specific Pkd1 kn...

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Bibliographic Details
Main Authors: Charles E MacKay, Miranda Floen, M Dennis Leo, Raquibul Hasan, Tessa AC Garrud, Carlos Fernández-Peña, Purnima Singh, Kafait U Malik, Jonathan H Jaggar
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-03-01
Series:eLife
Subjects:
polycystin-1
polycystin-2
endothelial cell
vasodilation
blood pressure
flow
Online Access:https://elifesciences.org/articles/74765

Internet

https://elifesciences.org/articles/74765

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