Treatment with Autophagy Inducer Trehalose Alleviates Memory and Behavioral Impairments and Neuroinflammatory Brain Processes in db/db Mice

Treatment with Autophagy Inducer Trehalose Alleviates Memory and Behavioral Impairments and Neuroinflammatory Brain Processes in db/db Mice

Autophagy attenuation has been found in neurodegenerative diseases, aging, diabetes mellitus, and atherosclerosis. In experimental models of neurodegenerative diseases, the correction of autophagy in the brain reverses neuronal and behavioral deficits and hence seems to be a promising therapy for ne...

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Bibliographic Details
Main Authors: Tatiana A. Korolenko, Nina I. Dubrovina, Marina V. Ovsyukova, Nataliya P. Bgatova, Michael V. Tenditnik, Alexander B. Pupyshev, Anna A. Akopyan, Natalya V. Goncharova, Chih-Li Lin, Evgeny L. Zavjalov, Maria A. Tikhonova, Tamara G. Amstislavskaya
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
leptin-deficient db/db mice
trehalose
autophagy
behavior
memory
obesity
Online Access:https://www.mdpi.com/2073-4409/10/10/2557

Internet

https://www.mdpi.com/2073-4409/10/10/2557

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