Role of Breast Cancer Risk Estimation Models to Identify Women Eligible for Genetic Testing and Risk-Reducing Surgery

Role of Breast Cancer Risk Estimation Models to Identify Women Eligible for Genetic Testing and Risk-Reducing Surgery

Hereditary breast and ovarian cancer (HBOC) syndrome is responsible for approximately 10% of breast cancers (BCs). The HBOC gene panel includes both high-risk genes, i.e., a four times higher risk of BC (<i>BRCA1</i>, <i>BRCA2</i>, <i>PALB2</i>, <i>CDH1</...

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Bibliographic Details
Main Authors: Azzurra Irelli, Leonardo Valerio Patruno, Sofia Chiatamone Ranieri, Daniela Di Giacomo, Sara Malatesta, Edoardo Alesse, Alessandra Tessitore, Katia Cannita
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Biomedicines
Subjects:
hereditary breast and ovarian cancer syndrome
pathogenic germline variants
breast cancer risk estimation models
primary prevention
risk-reducing mastectomy
risk-reducing salpingo-ovariectomy
Online Access:https://www.mdpi.com/2227-9059/12/4/714

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https://www.mdpi.com/2227-9059/12/4/714

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