Physiological and genetic analysis of multiple sodium channel variants in a model of genetic absence epilepsy

Physiological and genetic analysis of multiple sodium channel variants in a model of genetic absence epilepsy

In excitatory neurons, SCN2A (NaV1.2) and SCN8A (NaV1.6) sodium channels are enriched at the axon initial segment. NaV1.6 is implicated in several mouse models of absence epilepsy, including a missense mutation identified in a chemical mutagenesis screen (Scn8aV929F). Here, we confirmed the prior su...

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Bibliographic Details
Main Authors: M.K. Oliva, T.C. McGarr, B.J. Beyer, E. Gazina, D.I. Kaplan, L. Cordeiro, E. Thomas, S.D. Dib-Hajj, S.G. Waxman, W.N. Frankel, S. Petrou
Format: Article
Language:English
Published: Elsevier 2014-07-01
Series:Neurobiology of Disease
Subjects:
Absence seizures
Genetic epilepsy
Sodium channels
Murine AE
Computational analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000680

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http://www.sciencedirect.com/science/article/pii/S0969996114000680

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