Da-Chai-Hu-Tang Protects From Acute Intrahepatic Cholestasis by Inhibiting Hepatic Inflammation and Bile Accumulation via Activation of PPARα

Da-Chai-Hu-Tang Protects From Acute Intrahepatic Cholestasis by Inhibiting Hepatic Inflammation and Bile Accumulation via Activation of PPARα

Cholestasis is caused by intrahepatic retention of excessive toxic bile acids and ultimately results in hepatic failure. Da-Chai-Hu-Tang (DCHT) has been used in China to treat liver and gallbladder diseases for over 1800 years. Here, we demonstrated that DCHT treatment prevented acute intrahepatic c...

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Bibliographic Details
Main Authors: Shihao Xu, Xi Qiao, Peike Peng, Ziyi Zhu, Yaoting Li, Mengyuan Yu, Long Chen, Yin Cai, Jin Xu, Xinwei Shi, Christopher G. Proud, Jianling Xie, Kaikai Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
Da-Chai-Hu-Tang
intrahepatic cholestasis
liver injury
bile acid homeostasis
peroxisome proliferator-activated receptor alpha
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.847483/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.847483/full

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