C-X-C domain ligand 14-mediated stromal cell–macrophage interaction as a therapeutic target for hand dermal fibrosis

Abstract Dupuytren’s contracture, a superficial dermal fibrosis, causes flexion contracture of the affected finger, impairing hand function. Specific single-nucleotide polymorphisms within genes in the Wnt signalling pathway are associated with the disease. However, the precise role of Wnt signallin...

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Bibliographic Details
Main Authors: Atsushi Goto, Shingo Komura, Koki Kato, Rie Maki, Akihiro Hirakawa, Hiroyuki Tomita, Akihiro Hirata, Yasuhiro Yamada, Haruhiko Akiyama
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05558-8