6-Phosphogluconolactonase Promotes Hepatocellular Carcinogenesis by Activating Pentose Phosphate Pathway

6-Phosphogluconolactonase Promotes Hepatocellular Carcinogenesis by Activating Pentose Phosphate Pathway

Hepatocellular carcinoma (HCC) has a poor prognosis due to the rapid disease progression and early metastasis. The metabolism program determines the proliferation and metastasis of HCC; however, the metabolic approach to treat HCC remains uncovered. Here, by analyzing the liver cell single-cell sequ...

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Bibliographic Details
Main Authors: Changzheng Li, Jie Chen, Yishan Li, Binghuo Wu, Zhitao Ye, Xiaobin Tian, Yan Wei, Zechen Hao, Yuan Pan, Hongli Zhou, Keyue Yang, Zhiqiang Fu, Jingbo Xu, Yanan Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
hepatocellular carcinoma
6-phosphogluconolactonase
metabolic reprogramming
pentose phosphate pathway
ROS
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.753196/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.753196/full

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