In Silico Study of Correlation between Missense Variations of F8 Gene and Inhibitor Formation in Severe Hemophilia A

In Silico Study of Correlation between Missense Variations of F8 Gene and Inhibitor Formation in Severe Hemophilia A

Objective: Deleterious substitutions of the F8 gene are responsible for causing hemophilia A, which is an inherited bleeding disorder resulting from reduced or absent activity of the coagulant protein factor VIII (FVIII). The most important complication in treatment is inhibitor development toward t...

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Bibliographic Details
Main Authors: Mostefa Fodil, Faouzia Zemani
Format: Article
Language:English
Published: Galenos Publishing House 2020-05-01
Series:Turkish Journal of Hematology
Subjects:
hemophilia a
missense variation
in silico analysis
inhibitor formation
fviii
coagulation
Online Access:https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-09633

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https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-09633

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