p50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-κB complexes

p50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-κB complexes

Deregulated expression of COX-2 has been causally linked to development, progression, and outcome of several types of human cancer. We describe a novel fundamental level of transcriptional control of COX-2 expression. Using primary human mammary epithelial cells and monocyte/macrophage cell lines, w...

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Bibliographic Details
Main Authors: Michal Krawczyk, Beverly M Emerson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-04-01
Series:eLife
Subjects:
long non-coding RNA
Cyclooxygenase 2
NF-κB
CTCF
p300
transcription
Online Access:https://elifesciences.org/articles/01776

Internet

https://elifesciences.org/articles/01776

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