Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium

Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium

IntroductionCryptosporidiosis is a leading cause of diarrheal-associated morbidity and mortality, predominantly affecting children under 5 years old in low-and-middle-income countries. There is no effective treatment and no vaccine. New therapeutics are emerging from drug discovery efforts. It is cr...

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Bibliographic Details
Main Authors: Jack C. Hanna, Victor Corpas-Lopez, Simona Seizova, Beatrice L. Colon, Ross Bacchetti, Grant M. J. Hall, Emma M. Sands, Lee Robinson, Beatriz Baragaña, Susan Wyllie, Mattie C. Pawlowic
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
cryptosporidiosis
mode of action
aminoacyl-tRNA synthtase
tRNA synthetase inhibitor
selection marker
genetic cross
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1236814/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2023.1236814/full

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