Direct observation of frequency modulated transcription in single cells using light activation

Direct observation of frequency modulated transcription in single cells using light activation

Single-cell analysis has revealed that transcription is dynamic and stochastic, but tools are lacking that can determine the mechanism operating at a single gene. Here we utilize single-molecule observations of RNA in fixed and living cells to develop a single-cell model of steroid-receptor mediated...

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Bibliographic Details
Main Authors: Daniel R Larson, Christoph Fritzsch, Liang Sun, Xiuhau Meng, David S Lawrence, Robert H Singer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-09-01
Series:eLife
Subjects:
transcription factor
gene expression
single-molecule
fluorescence
Online Access:https://elifesciences.org/articles/00750

Internet

https://elifesciences.org/articles/00750

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