Clinical Implications of the Association between Respiratory and Gastrointestinal Disorders in Migraine and Non-Migraine Headache Patients
Headaches, particularly migraine, are associated with gastrointestinal (GI) disorders. In addition to the gut–brain axis, the lung–brain axis is suspected to be involved in the relationship between pulmonary microbes and brain disorders. Therefore, we investigated possible associations of migraine a...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/10/3434 |
| _version_ | 1797599693765607424 |
|---|---|
| author | Jong-Ho Kim Yeonkyeong Lee Young-Suk Kwon Jong-Hee Sohn |
| author_facet | Jong-Ho Kim Yeonkyeong Lee Young-Suk Kwon Jong-Hee Sohn |
| author_sort | Jong-Ho Kim |
| collection | DOAJ |
| description | Headaches, particularly migraine, are associated with gastrointestinal (GI) disorders. In addition to the gut–brain axis, the lung–brain axis is suspected to be involved in the relationship between pulmonary microbes and brain disorders. Therefore, we investigated possible associations of migraine and non-migraine headaches (nMH) with respiratory and GI disorders using the clinical data warehouse over 11 years. We compared data regarding GI and respiratory disorders, including asthma, bronchitis, and COPD, among patients with migraine, patients with nMH, and controls. In total, 22,444 patients with migraine, 117,956 patients with nMH, and 289,785 controls were identified. After adjustment for covariates and propensity score matching, the odds ratios (ORs) for asthma (1.35), gastroesophageal reflux disorder (1.55), gastritis (1.90), functional GI disorder (1.35), and irritable bowel syndrome (1.76) were significantly higher in patients with migraine than in controls (<i>p</i> = 0.000). The ORs for asthma (1.16) and bronchitis (1.33) were also significantly higher in patients with nMH than in controls (<i>p</i> = 0.0002). When the migraine group was compared with the nMH group, only the OR for GI disorders was statistically significant. Our findings suggest that migraine and nMH are associated with increased risks of GI and respiratory disorders. |
| first_indexed | 2024-03-11T03:37:55Z |
| format | Article |
| id | doaj.art-d0129d028f74412eb510e0d55a3a9818 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T03:37:55Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-d0129d028f74412eb510e0d55a3a98182023-11-18T01:52:59ZengMDPI AGJournal of Clinical Medicine2077-03832023-05-011210343410.3390/jcm12103434Clinical Implications of the Association between Respiratory and Gastrointestinal Disorders in Migraine and Non-Migraine Headache PatientsJong-Ho Kim0Yeonkyeong Lee1Young-Suk Kwon2Jong-Hee Sohn3Department of Anesthesiology and Pain Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 24253, Republic of KoreaInstitute of New Frontier Research Team, College of Medicine, Hallym University, Chuncheon 24252, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 24253, Republic of KoreaInstitute of New Frontier Research Team, College of Medicine, Hallym University, Chuncheon 24252, Republic of KoreaHeadaches, particularly migraine, are associated with gastrointestinal (GI) disorders. In addition to the gut–brain axis, the lung–brain axis is suspected to be involved in the relationship between pulmonary microbes and brain disorders. Therefore, we investigated possible associations of migraine and non-migraine headaches (nMH) with respiratory and GI disorders using the clinical data warehouse over 11 years. We compared data regarding GI and respiratory disorders, including asthma, bronchitis, and COPD, among patients with migraine, patients with nMH, and controls. In total, 22,444 patients with migraine, 117,956 patients with nMH, and 289,785 controls were identified. After adjustment for covariates and propensity score matching, the odds ratios (ORs) for asthma (1.35), gastroesophageal reflux disorder (1.55), gastritis (1.90), functional GI disorder (1.35), and irritable bowel syndrome (1.76) were significantly higher in patients with migraine than in controls (<i>p</i> = 0.000). The ORs for asthma (1.16) and bronchitis (1.33) were also significantly higher in patients with nMH than in controls (<i>p</i> = 0.0002). When the migraine group was compared with the nMH group, only the OR for GI disorders was statistically significant. Our findings suggest that migraine and nMH are associated with increased risks of GI and respiratory disorders.https://www.mdpi.com/2077-0383/12/10/3434migrainerespiratory disordersheadachegastrointestinal disordersasthma |
| spellingShingle | Jong-Ho Kim Yeonkyeong Lee Young-Suk Kwon Jong-Hee Sohn Clinical Implications of the Association between Respiratory and Gastrointestinal Disorders in Migraine and Non-Migraine Headache Patients Journal of Clinical Medicine migraine respiratory disorders headache gastrointestinal disorders asthma |
| title | Clinical Implications of the Association between Respiratory and Gastrointestinal Disorders in Migraine and Non-Migraine Headache Patients |
| title_full | Clinical Implications of the Association between Respiratory and Gastrointestinal Disorders in Migraine and Non-Migraine Headache Patients |
| title_fullStr | Clinical Implications of the Association between Respiratory and Gastrointestinal Disorders in Migraine and Non-Migraine Headache Patients |
| title_full_unstemmed | Clinical Implications of the Association between Respiratory and Gastrointestinal Disorders in Migraine and Non-Migraine Headache Patients |
| title_short | Clinical Implications of the Association between Respiratory and Gastrointestinal Disorders in Migraine and Non-Migraine Headache Patients |
| title_sort | clinical implications of the association between respiratory and gastrointestinal disorders in migraine and non migraine headache patients |
| topic | migraine respiratory disorders headache gastrointestinal disorders asthma |
| url | https://www.mdpi.com/2077-0383/12/10/3434 |
| work_keys_str_mv | AT jonghokim clinicalimplicationsoftheassociationbetweenrespiratoryandgastrointestinaldisordersinmigraineandnonmigraineheadachepatients AT yeonkyeonglee clinicalimplicationsoftheassociationbetweenrespiratoryandgastrointestinaldisordersinmigraineandnonmigraineheadachepatients AT youngsukkwon clinicalimplicationsoftheassociationbetweenrespiratoryandgastrointestinaldisordersinmigraineandnonmigraineheadachepatients AT jongheesohn clinicalimplicationsoftheassociationbetweenrespiratoryandgastrointestinaldisordersinmigraineandnonmigraineheadachepatients |