Tackling of Immunorefractory Tumors by Targeting Alternative Immune Checkpoints

Tackling of Immunorefractory Tumors by Targeting Alternative Immune Checkpoints

Physiologically, well known or traditional immune checkpoints (ICs), such as CTLA-4 and PD-1, are in place to promote tolerance to self-antigens and prevent generation of autoimmunity. In cancer, the ICs are effectively engaged by the tumor cells or stromal ells from the tumor microenvironment throu...

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Bibliographic Details
Main Authors: Dharmindra Dulal, Andrew Boring, David Terrero, Tiffany Johnson, Amit K. Tiwari, Dayanidhi Raman
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cancers
Subjects:
immuno-refractory tumors
CD8<sup>+</sup> T lymphocytes
immunosuppression
immunotherapy
PD-1
immune checkpoints
Online Access:https://www.mdpi.com/2072-6694/15/10/2774

Internet

https://www.mdpi.com/2072-6694/15/10/2774

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