Desmin and Plectin Recruitment to the Nucleus and Nuclei Orientation Are Lost in Emery-Dreifuss Muscular Dystrophy Myoblasts Subjected to Mechanical Stimulation

Desmin and Plectin Recruitment to the Nucleus and Nuclei Orientation Are Lost in Emery-Dreifuss Muscular Dystrophy Myoblasts Subjected to Mechanical Stimulation

In muscle cells subjected to mechanical stimulation, LINC complex and cytoskeletal proteins are basic to preserve cellular architecture and maintain nuclei orientation and positioning. In this context, the role of lamin A/C remains mostly elusive. This study demonstrates that in human myoblasts subj...

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Bibliographic Details
Main Authors: Vittoria Cenni, Camilla Evangelisti, Spartaco Santi, Patrizia Sabatelli, Simona Neri, Marco Cavallo, Giovanna Lattanzi, Elisabetta Mattioli
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cells
Subjects:
lamin A/C
LINC complex
Emery-Dreifuss Muscular Dystrophy (EDMD)
desmin
plectin
mechanical stretching
Online Access:https://www.mdpi.com/2073-4409/13/2/162

Internet

https://www.mdpi.com/2073-4409/13/2/162

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