Targeted systemic dendrimer delivery of CSF‐1R inhibitor to tumor‐associated macrophages improves outcomes in orthotopic glioblastoma

Targeted systemic dendrimer delivery of CSF‐1R inhibitor to tumor‐associated macrophages improves outcomes in orthotopic glioblastoma

Abstract Glioblastoma is the most common and aggressive form of primary brain cancer, with median survival of 16–20 months and a 5‐year survival rates of <5%. Recent advances in immunotherapies have shown that addressing the tumor immune profile by targeting the colony‐stimulating factor 1 (CSF‐1...

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Bibliographic Details
Main Authors: Kevin Liaw, Rajsekhar Reddy, Anjali Sharma, Jiangyu Li, Michelle Chang, Rishi Sharma, Sebastian Salazar, Sujatha Kannan, Rangaramanujam M. Kannan
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Bioengineering & Translational Medicine
Subjects:
dendrimer
glioblastoma
immunotherapy
systemic
targeted delivery
tumor‐associated macrophage
Online Access:https://doi.org/10.1002/btm2.10205

Internet

https://doi.org/10.1002/btm2.10205

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