AChR β-Subunit mRNAs Are Stabilized by HuR in a Mouse Model of Congenital Myasthenic Syndrome With Acetylcholinesterase Deficiency

AChR β-Subunit mRNAs Are Stabilized by HuR in a Mouse Model of Congenital Myasthenic Syndrome With Acetylcholinesterase Deficiency

Collagen Q (COLQ) is a specific collagen that anchors acetylcholinesterase (AChE) in the synaptic cleft of the neuromuscular junction. So far, no mutation has been identified in the ACHE human gene but over 50 different mutations in the COLQ gene are causative for a congenital myasthenic syndrome (C...

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Bibliographic Details
Main Authors: Jennifer Karmouch, Perrine Delers, Fannie Semprez, Nouha Soyed, Julie Areias, Guy Bélanger, Aymeric Ravel-Chapuis, Alexandre Dobbertin, Bernard J. Jasmin, Claire Legay
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neuromuscular junction
congenital myasthenic syndromes
p38 MAPK
HuR
acetylcholine receptor mRNA
ColQ
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2020.568171/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2020.568171/full

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