Enhanced amphiregulin exposure promotes modulation of the high grade serous ovarian cancer tumor immune microenvironment

Enhanced amphiregulin exposure promotes modulation of the high grade serous ovarian cancer tumor immune microenvironment

High grade serous ovarian cancer (HGSOC) is a lethal gynecologic malignancy in which chemoresistant recurrence rates remain high. Furthermore, HGSOC patients have demonstrated overall low response rates to clinically available immunotherapies. Amphiregulin (AREG), a low affinity epidermal growth fac...

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Bibliographic Details
Main Authors: Jasmine Ebott, Julia McAdams, Chloe Kim, Corrine Jansen, Morgan Woodman, Payton De La Cruz, Christoph Schrol, Jennifer Ribeiro, Nicole James
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Pharmacology
Subjects:
amphiregulin (AREG)
high-grade serous ovarian cancer
tumor immune microenvioronment
immunosupperssion
chemoresistance
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1375421/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1375421/full

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