Function Control of Anti-microRNA Oligonucleotides Using Interstrand Cross-Linked Duplexes

Function Control of Anti-microRNA Oligonucleotides Using Interstrand Cross-Linked Duplexes

MicroRNA (miRNA)-guided argonaute (Ago) controls gene expression upon binding to the 3′ UTR of mRNA. The miRNA function can be competitively inhibited by single-stranded anti-miRNA oligonucleotides (AMOs). In this study, we constructed a novel type of AMO flanked by interstrand cross-linked 2′-O-met...

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Bibliographic Details
Main Authors: Yasuhiro Mie, Yu Hirano, Keiko Kowata, Akiyoshi Nakamura, Mayu Yasunaga, Yoshihiro Nakajima, Yasuo Komatsu
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
microRNA
antisense
cross-link
duplex
argonaute
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117302871

Internet

http://www.sciencedirect.com/science/article/pii/S2162253117302871

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