The urinary excretion of epigenetically modified DNA as a marker of pediatric ALL status and chemotherapy response

The urinary excretion of epigenetically modified DNA as a marker of pediatric ALL status and chemotherapy response

Abstract The active DNA demethylation process may be linked to aberrant methylation and may be involved in leukemogenesis. We investigated the role of epigenetic DNA modifications in childhood acute lymphoblastic leukemia (ALL) diagnostics and therapy monitoring. We analyzed the levels of 5-methyl-2...

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Main Authors: Rafal Rozalski, Daniel Gackowski, Aleksandra Skalska-Bugala, Marta Starczak, Agnieszka Siomek-Gorecka, Ewelina Zarakowska, Martyna Modrzejewska, Tomasz Dziaman, Anna Szpila, Kinga Linowiecka, Jolanta Guz, Justyna Szpotan, Maciej Gawronski, Anna Labejszo, Lidia Gackowska, Marek Foksinski, Elwira Olinska, Aleksandra Wasilow, Andrzej Koltan, Jan Styczynski, Ryszard Olinski
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-00880-9

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https://doi.org/10.1038/s41598-021-00880-9

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