AdipoRon alleviates fatty acid–induced lipid accumulation and mitochondrial dysfunction in bovine hepatocytes by promoting autophagy

AdipoRon alleviates fatty acid–induced lipid accumulation and mitochondrial dysfunction in bovine hepatocytes by promoting autophagy

ABSTRACT: During the transition period in dairy cows, high circulating concentrations of nonesterified fatty acids (NEFA) increase hepatic lipid deposits and are considered a major pathological factor for liver damage. We investigated whether AdipoRon, a synthetic small-molecule agonist of adiponect...

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Bibliographic Details
Main Authors: Chenchen Zhao, Bing Wu, Jinxia Li, Qianming Jiang, Juan J. Loor, Menglin Liu, Linfang Chen, Yiwei Zhu, Wenwen Gao, Xiliang Du, Yuxiang Song, Guowen Liu, Lin Lei, Xinwei Li
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Journal of Dairy Science
Subjects:
AdipoRon
nonesterified fatty acids
autophagy
lipid accumulation
mitochondrial dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S0022030223002953

Internet

http://www.sciencedirect.com/science/article/pii/S0022030223002953

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