Neuronal firing activity and gene expression changes in the subthalamic nucleus after transplantation of dopamine neurons in hemiparkinsonian rats

Neuronal firing activity and gene expression changes in the subthalamic nucleus after transplantation of dopamine neurons in hemiparkinsonian rats

Dopamine (DA) depletion in the nigrostriatal system leads to basal ganglia dysfunction both in Parkinson's disease (PD) and in 6-hydroxy dopamine (6-OHDA)-lesioned rats with neuronal hyperactivity in the subthalamic nucleus (STN), i.e. increased firing rate and burst activity, together with enh...

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Bibliographic Details
Main Authors: Regina Rumpel, Mesbah Alam, Alexander Klein, Meltem Özer, Maike Wesemann, Xingxing Jin, Joachim K. Krauss, Kerstin Schwabe, Andreas Ratzka, Claudia Grothe
Format: Article
Language:English
Published: Elsevier 2013-11-01
Series:Neurobiology of Disease
Subjects:
Transplantation
Brain repair
Embryonic tissue
Drug-induced rotation
6-OHDA
RT-PCR
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113002179

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http://www.sciencedirect.com/science/article/pii/S0969996113002179

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