The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection

The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection

Summary: Activation of endosomal Toll-like receptor (TLR) 7, TLR9, and TLR11/12 is a key event in the resistance against the parasite Toxoplasma gondii. Endosomal TLR engagement leads to expression of interleukin (IL)-12 via the myddosome, a protein complex containing MyD88 and IL-1 receptor-associa...

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Bibliographic Details
Main Authors: Milton Pereira, Theresa Ramalho, Warrison A. Andrade, Danielle F. Durso, Maria C. Souza, Katherine A. Fitzgerald, Douglas T. Golenbock, Neal Silverman, Ricardo T. Gazzinelli
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724001232

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http://www.sciencedirect.com/science/article/pii/S2211124724001232

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