Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome

Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome

Abstract Background Oral administration is the most common way to deliver drugs to the systemic circulation or target organs. Orally administered drugs are absorbed in the intestine and metabolized in the intestine and liver. In the early stages of drug development, it is important to predict first-...

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Bibliographic Details
Main Authors: Yumi Ohta, Kanako Kazuki, Satoshi Abe, Mitsuo Oshimura, Kaoru Kobayashi, Yasuhiro Kazuki
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Biotechnology
Subjects:
Mammalian artificial chromosome
Chromosome transfer
Cytochrome P450
Intestinal metabolism
Caco-2 cell
Online Access:http://link.springer.com/article/10.1186/s12896-020-00637-8

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http://link.springer.com/article/10.1186/s12896-020-00637-8

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