393 Harnessing the potential of transcriptional adaptation as a mechanism for rare Amyotrophic lateral sclerosis

OBJECTIVES/GOALS: Transcriptional adaptation is a phenomenon in which a mutation in one gene leads to the genetic compensation of another homogenous gene. Understanding the mechanism of transcriptional adaptation may contribute to an explanation for variation in clinical manifestations of rare Amyot...

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Bibliographic Details
Main Authors: Adriana Morales Gomez, Nathan Staff, Stephen C. Ekker
Format: Article
Language:English
Published: Cambridge University Press 2024-04-01
Series:Journal of Clinical and Translational Science
Online Access:https://www.cambridge.org/core/product/identifier/S2059866124003431/type/journal_article