Recapitulation of methotrexate hepatotoxicity with induced pluripotent stem cell-derived hepatocytes from patients with rheumatoid arthritis

Recapitulation of methotrexate hepatotoxicity with induced pluripotent stem cell-derived hepatocytes from patients with rheumatoid arthritis

Abstract Background Methotrexate (MTX) is widely used for the treatment of rheumatoid arthritis (RA). The drug is cost-effective, but sometimes causes hepatotoxicity, requiring a physician’s attention. In this study, we simulated hepatotoxicity by treating hepatocytes derived from RA patient–derived...

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Bibliographic Details
Main Authors: Juryun Kim, Yena Kim, Jinhyeok Choi, Hyerin Jung, Kijun Lee, Jaewoo Kang, Narae Park, Yeri Alice Rim, Yoojun Nam, Ji Hyeon Ju
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Stem Cell Research & Therapy
Subjects:
Induced pluripotent stem cells
Hepatocyte
Hepatocyte spheroid
Methotrexate
Drug-induced hepatotoxicity
Rheumatoid arthritis
Online Access:http://link.springer.com/article/10.1186/s13287-018-1100-1

Internet

http://link.springer.com/article/10.1186/s13287-018-1100-1

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