Multiple Timescale Dynamic Analysis of Functionally-Impairing Mutations in Human Ileal Bile Acid-Binding Protein

Multiple Timescale Dynamic Analysis of Functionally-Impairing Mutations in Human Ileal Bile Acid-Binding Protein

Human ileal bile acid-binding protein (hI-BABP) has a key role in the enterohepatic circulation of bile salts. Its two internal binding sites exhibit positive cooperativity accompanied by a site-selectivity of glycocholate (GCA) and glycochenodeoxycholate (GCDA), the two most abundant bile salts in...

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Bibliographic Details
Main Authors: Gergő Horváth, Bence Balterer, András Micsonai, József Kardos, Orsolya Toke
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
bile acids
enterohepatic circulation
intracellular lipid-binding proteins
ligand binding
NMR spectroscopy
positive cooperativity
Online Access:https://www.mdpi.com/1422-0067/23/19/11346

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https://www.mdpi.com/1422-0067/23/19/11346

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