Effects of PCSK9 inhibition on glucose metabolism and β-cell function in humans: a pilot study

Effects of PCSK9 inhibition on glucose metabolism and β-cell function in humans: a pilot study

BackgroundAnti-PCSK9 monoclonal antibodies are effective in reducing LDL-C and cardiovascular events by neutralizing circulating PCSK9. PCSK9, however, is also expressed in tissues, including the pancreas, and studies on PCSK9 KO mice have shown impaired insulin secretion. Statin treatment is alread...

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Bibliographic Details
Main Authors: Simona Moffa, Teresa Mezza, Pietro Manuel Ferraro, Gianfranco Di Giuseppe, Chiara M. A. Cefalo, Francesca Cinti, Flavia Impronta, Umberto Capece, Gea Ciccarelli, Andrea Mari, Alfredo Pontecorvi, Andrea Giaccari
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Endocrinology
Subjects:
PCSK 9 inhibition
diabetes
β-cell
statins
precision medicine
BMI
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1124116/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1124116/full

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