Endothelial edema precedes blood-brain barrier breakdown in early time points after experimental focal cerebral ischemia

Endothelial edema precedes blood-brain barrier breakdown in early time points after experimental focal cerebral ischemia

Abstract In the setting of stroke, ischemia-related blood-brain barrier (BBB) dysfunction aggravates the cerebral edema, which critically impacts on the clinical outcome. Further, an impaired vascular integrity is associated with the risk of intracranial bleeding, especially after therapeutic recana...

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Bibliographic Details
Main Authors: Martin Krueger, Bianca Mages, Constance Hobusch, Dominik Michalski
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Acta Neuropathologica Communications
Subjects:
Stroke
Blood-brain barrier
Endothelium
Edema
Tight junctions
Online Access:http://link.springer.com/article/10.1186/s40478-019-0671-0

Internet

http://link.springer.com/article/10.1186/s40478-019-0671-0

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