G Protein-Coupled Receptor Signaling Analysis Using Homogenous Time-Resolved Förster Resonance Energy Transfer (HTRF®) Technology

G Protein-Coupled Receptor Signaling Analysis Using Homogenous Time-Resolved Förster Resonance Energy Transfer (HTRF®) Technology

Studying multidimensional signaling of G protein-coupled receptors (GPCRs) in search of new and better treatments requires flexible, reliable and sensitive assays in high throughput screening (HTS) formats. Today, more than half of the detection techniques used in HTS are based on fluorescence, beca...

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Bibliographic Details
Main Authors: Lenea Nørskov-Lauritsen, Alex Rojas Bie Thomsen, Hans Bräuner-Osborne
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:International Journal of Molecular Sciences
Subjects:
G protein-coupled receptor (GPCR)
signaling pathway
high throughput screening (HTS)
homogenous time-resolved Förster resonance energy transfer (HTRF®)
D-myo-inositol 1-phosphate (IP1)
cyclic adenosine 3',5'-monophosphate (cAMP)
extracellular signal-regulated kinases (ERK1/2)
Online Access:http://www.mdpi.com/1422-0067/15/2/2554

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http://www.mdpi.com/1422-0067/15/2/2554

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