Notch3-Dependent Effects on Adult Neurogenesis and Hippocampus-Dependent Learning in a Modified Transgenic Model of CADASIL

Notch3-Dependent Effects on Adult Neurogenesis and Hippocampus-Dependent Learning in a Modified Transgenic Model of CADASIL

We and others have reported that Notch3 is a regulator of adult hippocampal neurogenesis. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), the most common genetic form of vascular dementia, is caused by mutations in Notch3. The present study inten...

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Bibliographic Details
Main Authors: Fanny Ehret, Ricardo Moreno Traspas, Marie-Theres Neumuth, Bianca Hamann, Daniela Lasse, Gerd Kempermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
adult neurogenesis
CADASIL
dentate gyrus
hippocampus
Notch3
spatial learning
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.617733/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.617733/full

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