Schisandrin B Antagonizes Cardiotoxicity Induced by Pirarubicin by Inhibiting Mitochondrial Permeability Transition Pore (mPTP) Opening and Decreasing Cardiomyocyte Apoptosis

Schisandrin B Antagonizes Cardiotoxicity Induced by Pirarubicin by Inhibiting Mitochondrial Permeability Transition Pore (mPTP) Opening and Decreasing Cardiomyocyte Apoptosis

Objective: Pirarubicin (THP), one of the anthracycline anticancer drugs, is widely used in the treatment of various cancers, but its cardiotoxicity cannot be ignored. Schisandrin B (SchB) has the ability to upregulate cellular antioxidant defense mechanism and promote mitochondrial function and anti...

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Bibliographic Details
Main Authors: Hongwei Shi, Heng Tang, Wen Ai, Qingfu Zeng, Hong Yang, Fengqing Zhu, Yunjie Wei, Rui Feng, Li Wen, Peng Pu, Quan He
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Pharmacology
Subjects:
antiapoptotic
cardiotoxicity
schisandrin B
pirarubicin (THP)
MPTP
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.733805/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.733805/full

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