Type I interferon (IFN)-inducible Absent in Melanoma 2 proteins in neuroinflammation: implications for Alzheimer’s disease

Type I interferon (IFN)-inducible Absent in Melanoma 2 proteins in neuroinflammation: implications for Alzheimer’s disease

Abstract Cumulative evidence indicates that activation of innate immune responses in the central nervous system (CNS) induces the expression of type 1 interferons (T1 IFNs), a family of cytokines. The T1 IFNs (IFN-α/β), through activation of the JAK/STAT-signaling in microglia, astrocytes, and neuro...

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Bibliographic Details
Main Author: Divaker Choubey
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Neuroinflammation
Subjects:
Type I IFNs
Alzheimer’s disease
Neuroinflammation
AIM2 proteins
Online Access:http://link.springer.com/article/10.1186/s12974-019-1639-5

Internet

http://link.springer.com/article/10.1186/s12974-019-1639-5

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