The acidic intrinsically disordered region of the inflammatory mediator HMGB1 mediates fuzzy interactions with CXCL12

The acidic intrinsically disordered region of the inflammatory mediator HMGB1 mediates fuzzy interactions with CXCL12

Abstract Chemokine heterodimers activate or dampen their cognate receptors during inflammation. The CXCL12 chemokine forms with the fully reduced (fr) alarmin HMGB1 a physiologically relevant heterocomplex (frHMGB1•CXCL12) that synergically promotes the inflammatory response elicited by the G-protei...

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Bibliographic Details
Main Authors: Malisa Vittoria Mantonico, Federica De Leo, Giacomo Quilici, Liam Sean Colley, Francesco De Marchis, Massimo Crippa, Rosanna Mezzapelle, Tim Schulte, Chiara Zucchelli, Chiara Pastorello, Camilla Carmeno, Francesca Caprioglio, Stefano Ricagno, Gabriele Giachin, Michela Ghitti, Marco Emilio Bianchi, Giovanna Musco
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45505-7

Internet

https://doi.org/10.1038/s41467-024-45505-7

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