Small methyltransferase RlmH assembles a composite active site to methylate a ribosomal pseudouridine

Abstract Eubacterial ribosomal large-subunit methyltransferase H (RlmH) methylates 23S ribosomal RNA pseudouridine 1915 (Ψ1915), which lies near the ribosomal decoding center. The smallest member of the SPOUT superfamily of methyltransferases, RlmH lacks the RNA recognition domain found in larger me...

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Bibliographic Details
Main Authors: Cha San Koh, Rohini Madireddy, Timothy J. Beane, Phillip D. Zamore, Andrei A. Korostelev
Format: Article
Language:English
Published: Nature Portfolio 2017-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-01186-5