Sumoylation of Hes6 Regulates Protein Degradation and Hes1-Mediated Transcription

Sumoylation of Hes6 Regulates Protein Degradation and Hes1-Mediated Transcription

BackgroundHes6 is a transcriptional regulator that induces transcriptional activation by binding to transcription repressor Hes1 and suppressing its activity. Hes6 is controlled by the ubiquitin-proteosome-mediated degradation system. Here we investigated the sumoylation of Hes6 and its functional r...

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Bibliographic Details
Main Authors: Jiwon Lee, Sung Kook Chun, Gi Hoon Son, Kyungjin Kim
Format: Article
Language:English
Published: Korean Endocrine Society 2015-09-01
Series:Endocrinology and Metabolism
Subjects:
Hes6
Sumoylation
Ubiquitination
Degradation
Rhythmic expression
Online Access:http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-381.pdf

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