PCK1 activates oncogenic autophagy via down-regulation Serine phosphorylation of UBAP2L and antagonizes colorectal cancer growth

PCK1 activates oncogenic autophagy via down-regulation Serine phosphorylation of UBAP2L and antagonizes colorectal cancer growth

Abstract Phosphoenolpyruvate carboxykinase 1 (PCK1) is the rate-limiting enzyme in gluconeogenesis. PCK1 is considered an anti-oncogene in several human cancers. In this study, we aimed to determine the functions of PCK1 in colorectal cancer (CRC). PCK1 expression in CRC tissues was tested by wester...

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Bibliographic Details
Main Authors: Xiangyan Zhang, Geru Tao, Jie Jiang, Tingting Qu, Shuchao Zhao, Ping Xu, Ya’nan Zhao, Xiaoming Xing, Shucun Qin
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Cancer Cell International
Subjects:
Phosphoenolpyruvate carboxykinase 1 (PCK1)
Ubiquitin-associated protein 2-like (UBAP2L)
Serine phosphorylation
Autophagy
Colorectal cancer
Online Access:https://doi.org/10.1186/s12935-023-02894-x

Internet

https://doi.org/10.1186/s12935-023-02894-x

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